What is MGN-3?


MGN-3 is an essential immune support dietary supplement that provides vital antioxidant and anti-inflammatory action.

The action ingredient in MGN-3, Rice Bran Arabinoxylan Compound (RBAC) will help your body maintain peak immune system activity for as long as you keep taking it, never losing effectiveness over time. A polysaccharide dietary fiber derived from rice bran, RBAC is modified by an enzyme from the Shiitake mushroom using a patented biotechnology process. MGN-3 uses the powerful enzymes from the Shiitake mushroom to break up long-chain rice bran into short chain hemicellulose compounds which create the immunomodulatory effect. MGN-3’s immune enhancing effects starts in just a few days, and it takes only a few weeks for the immunomodulation effect to reach 90% of its peak.

Since MGN-3 was developed in 1990, it has been successfully taken by hundreds of thousands of individuals worldwide who have wanted to enhance their immune systems and it has established itself over the years as the most effective immune system supplement available worldwide, bar none.

Studies conducted in the United States, published in the International Journal of Immunology and presented at the Association of Abnormal cell Research and the International Conference on AIDS, show that MGN-3 can enhance NK cell activity by more than 300%, increase the activity of B-cells by 250% or greater, and boost T-cell activity by 200%.

What is its effect on the body?

HUMAN BODYMGN-3 arabinoxylan compound can stimulate a weak immune system (see right) more powerfully and safely than any other agent, natural or synthetic. In fact, Mamdooh Ghoneum, Professor of Immunology at the Charles R. Drew University of Medicine and Science, has stated that it is the most powerful immunomodulator he has ever tested. Although nobody yet knows the exact mechanism, it appears to be able to do this by increasing the body’s production of natural cytokynes — substances such as interferons, interleukins and tumour necrosis factors, which not only help destroy rogue cells and viruses directly, but kick-start the immune system by increase the activity of the lymphocytes — B cells, T cells and especially NK (natural killer) cells. B cells focus on producing antibodies whilst the T and NK cells wander through the body directly destroying virally or bacterially infected cells, and cells that have turned cancerous. (In its lifetime, a single NK cell can kill as many as 27 cancer cells, sticking to them and then injecting lethal chemical granules that can destroy the abnormal cell in less than 5 minutes.)

When the body is stressed or in a diseased state, the immune system can become overloaded and the activity of these protector cells becomes sluggish. This is often compounded by medical treatment – such as chemotherapy in the case of cancer – which further depresses the immune system. A weak immune system is less able to prevent cancer cells and infections from taking hold and spreading in the body.

It is extremely important to both disease prevention and disease treatment, therefore, to optimize the immune system, and especially NK cell activity, as these cells, which comprise 15% of the white blood cells, are considered the “elite troops” of the immune system, and any rise in their activity can increase the chance and speed of recovery. This is why research into immunomodulators often focus on this single parameter of NK cell activity: it is easy to measure in a laboratory with a 51Cr-release assay test and it gives a good indication or “snap shot” of overall immune system strength. Most of the research papers done on MGN-3, therefore, involve extensive NK cell activity testing, and it has been shown that  MGN-3 can stimulate sluggish NK cell activity by as much as 300% or more.


MGN-3 can also increase depressed T cell and B cell activity by 250% and 200% respectively, as well as other factors of the immune system such as TNF. And it can do this without any toxicity or other adverse side effects (unlike synthetic cytokines currently used by oncologists, such as interleukin-2, which can be extremely toxic).

The graph shows the increase in activity of NK cells with just two weeks on MGN-3 supplementation. This activity can be scientifically measured by placing blood from a patient into a vial of live cancer cells, and then using a radioactive marker to measure, after a four hour period, the percentage of these cells destroyed by the bloods NK cells. Although intake was stopped after this two week period for this experiment, you can see from the graph that the NK activity is still well above the control level a few weeks later.

Research has also shown that, provided MGN-3 is regularly included in the diet, this stimulation of the immune system need not decrease over time. This lack of a tail-off (or hyporesponsiveness) with prolonged use is extremely unusual for immunomodulatory substances and means that MGN-3 is always effective, even with prolonged use. NK activity usually peaks around 1 or 2 months after being on a high dose, after which it can be maintained with a smaller maintenance does (see dosages below). The speed at which this peak is reached depends on the amount taken each day.

anti inflammatoryMGN-3 has also recently been shown to have an anti-inflammatory effect in the body. Indeed, the head of the research department at Daiwa Pharmaceutical, Dr. Endo, first took MGN-3 himself for a painful rheumatoid arthritic condition in his hands, which subsequently cleared up. Apart from obvious inflammation (itis) problems in the body such as arthritis and allergies, inflammation is believed to increase the rate of cell mutation, and therefore reducing it could be helpful in minimising cancer risk.This ability to enhance the immune system and reduce inflammation means that MGN-3 is an important food supplement for a variety of situations. (Please note that the majority of research has been conducted in relation to cancer, and that more research needs to be done on viral infections, bacterial infections and diabetes.)

General health maintenance — Even in healthy people, MGN-3 helps to strengthen the immune system by increasing the activity of the white blood cells. This, in turn, increases immunity by enhancing the body’s ability to destroy infections and abnormal cells before they have a chance to spread. For those that are unwell, MGN-3 can help speed up recovery by increasing immune function.

stop cancerCancer — When used in conjunction with a good treatment program, MGN-3 can help the body increase its own survival chances by boosting white blood cell activity and promoting the rejection of abnormal cells. Also, it can improve the quality of life for those who are on chemotherapy and hormone therapy due to it ability to alleviate the side effects of the drugs used in these treatments. (Nausea and hair loss, for example, are often reduced.) Cancers of the blood, such as leukaemia and multiple myeloma show the greatest benefit, whilst good results have been seen in other cancers like lymphoma, ovarian, prostate and breast cancer (see clinical research for more detailed research results). It is important to note that MGN-3 itself is NOT a cancer treatment, but a useful adjuct or addition to a cancer treatment program supervised by a qualified practitioner. Proper treatments can dramatically reduce the load of cancer cells in the body (a process called debulking) whilst the MGN-3 can help the immune system manage the remainder. (Most of the research into the benefits of arabinoxylan on cancers have been carried out in conjunction with conventional cancer treatments.)

Viral infections such as HIV, AIDS and hepatitis B & C —MGN-3 has the ability to improve immunological parameters in patients with these conditions (such as Interferon-Gamma production, GOT, GPT and Gamma GPT). In vitro research shows that it can inhibit the replication of the HIV virus without toxicity. Once again,MGN-3 is not a treatment in itself, but a useful adjuct to a treatment program supervised by a qualified practitioner. (MGN-3 has had very limited success with Chronic Fatigue Syndrome, indicating that this condition is likely to be much more complex than a straightforward viral infection.)

BacteriaBacterial Infections such as colds, fevers and food poisoning —MGN-3 can help speed recovery alongside conventional treatments by strengthening the immune system. (Most of the evidence that MGN-3 can help with bacterial infections is anecdotal, although it is consistent with the activity of a stimulated immune system.)

Diabetes —MGN-3 has the ability to improve glucose tolerance — although it is NOT a substitute for insulin or for glucose monitoring. This is definitely an area that needs further research.

Inflammatory Conditions —MGN-3 reduces the inflammatory response in the body, helping to bring symptomatic relief for a variety of inflammatory conditions including arthritis. It does this by suppressing the infiltration of leukocytes, especially neutrophiles, into inflamed tissue. So far, there have been no human clinical trials on this ability of MGN-3. Recent research has also indicated that there is a strong link between an excessive inflammation response in the body and abnormal cell growth.

Allergies — Similar to the above, by reducing the inflammatory response, MGN-3 has the ability to reduce the symptoms of allergies. It does this by suppressing the degranulation of mast cells, the storehouses of histamine which causes the symptoms of allergy.

Does MGN-3 have any toxicity or side effects?

No. MGN-3 is a natural product that has no adverse or toxic side-effects, confirmed by blood tests and examinations of liver and kidney function of people who have taken high amounts of the compound over several months. The only obvious contraindication is that, as an immunomodulator, able to boost weak immune systems, it should not be taken in conjunction with any medication specifically for suppressing the immune system.

And, although mushroom enzymes are used in MGN-3’s manufacture, there is no mushroom content in the final product, which means that nearly all those with mushroom intolerances have been able to take it without an allergic reaction. This compound has also been authorized by the Japan Health Food and Nutrition Food Association, and has passed strict evaluation standards set under the guidance of the Ministry of Health and Welfare.

How much MGN-3 should I take and when

As the body does not build up a resistance to MGN-3 over time, this food supplement can safely and effectively be taken over an extended period of time, and without the necessity of slowly increasing the dosage as with other immunomodulators.

Most research into MGN-3 has been conducted using 30 to 45mg/kg/day in a divided dose with meals, with maintenance doses down to 15mg/kg/day. A dosage of at least 500mg a day should be taken for general health maintenance (unless potentised with yeast); for more serious immune support (such as in the case of arthritis, diabetes, hepatitis B, hepatitis C and other infections) the recommended dosage should be 1000mg a day; and for serious conditions where the immune system is severely compromised (such as with cancer or AIDS) 3g per day is recommended for 1 month and then 1g per day thereafter.

MGN-3 should always be taken after food (ideally, 30 minutes after) and larger daily intakes should be divided into three portions and taken with breakfast, lunch and dinner. If the person taking the compound is very ill, they can stay on the 3g per day intake for an extended period.

Apart from the case of general health maintenance, we always recommend that your doctor be informed that you are taking this supplement, so that he or she can integrate it into your treatment program intake for an extended period.

MGN-3 is an important supplement for a variety of situations. It will help your body maintain peak immune system activity for as long as you keep taking it never losing effectiveness.

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